What is the coating process? And with a large variety of pigmented and non-pigmented tablet film coating systems available, you can coat your products in a color of your choice with a cost-effective coating that can also provide protection from light, moisture and environmental gases. The continuous partial coating and recycling will eventually result in the tablet to be fully coated.
Equipment Efficiency – coating efficiency is achieved by dividing the net increase in the weight by the total of the nonvolatile coating applied to the tablet. When coating composition is applied to a batch of tablets in a coating pan, the tablet surfaces become covered with a tacky polymeric film. Film coating is a contemporary and widely used process for coating oral solid dosage forms in the pharmaceutical industry.
It is a process that draws on technologies associated with polymer chemistry, industrial adhesives and paints, and chemical engineering. Tablet coating checklist Since spraying, coating distribution, and drying take place at the same time, tablet coating is a dynamic, com-plex process that is affected by many variables. In no par-ticular order, here are some of the parameters that you should check when evaluating your coating operation to determine the source of defective coated.
Facility and ancillary equipment 4. Automation in coating process. Tablet Properties Tablets that are to be coated must possess the proper physical characteristics. In the coating process, the tablets roll in a coating pan or cascade in the air stream as the coating solution is applied.
Tablet coating is a common pharmaceutical technique of applying a thin polymer-based film to a tablet or a granule containing active pharmaceutical ingredients (APIs).
Tablet coatings must be stable and strong enough to survive the handling of the tablet , must not make tablets stick together during the coating process, and must follow the fine contours of embossed characters or logos on tablets. Coatings are necessary for tablets that have an unpleasant taste, and a smoother finish makes large tablets easier. Coating tablets with a thin polymer film can be an effective way to give your products a professional edge. High quality tablets can be quickly and easily produced using a tablet coating machine and the correct excipients.
Unfortunately several defects can arise with coatings. Tablet Coating System is an equipment that coats the external surface of tablet using a thin film of coating material. Machine is relatively simple where aplication of coating material is done on a moving bed of tablets and removing rapidly the solvents using current hot air. Tablets can either be ‘sugar coated ’, ‘film coated ’, ‘enteric coated ’ or coated to modify how the drug is released into the body (modified release).
Each of these coatings are there for different reasons and it is important to understand these reasons before deciding whether it is safe or appropriate to crush. Generally, as long as the tablet cores and coating formulation are suitably robust, the faster the tablet motion within the coating pan, the better. When designing coating processes, any limitations that exist with respect to either the tablet cores or the coating formulation must be taken into account.
A film coating is a thin polymer-based coat applied to a solid dosage form such as a tablet. It is possible to follow the dynamic curing effect on tablet coating structure by using non-destructive analytical methodologies. Enteric coating – tablets with an enteric coating should never be crushed.
The coating is designed to hold the tablet together in the stomach and may be there to protect the stomach from the medicine, protect the medicine from the acid in the stomach or to release the medicine after the stomach e. So far, it is one of those tablet coating machines that ensures consistent and accurate coating. As you can see, the working principle of all these tablet coating machines is the same.
For instance, in all the perforated pan systems, the spray nozzle atomizes coating fluid. Also, the spraying nozzle is in the tablet coating drum. These coaters differ in their function and application. Horizontal Pan Layers of coating spray are applied to the particles until a desired thickness is achieved. Film Coated Tablet (FCT) This type of coating is the most widely used.
The point is to beautify the tablets with a variety of colors, protect the tablet to remain stable and cover up a bad taste. The tablet coating have number of advantages like masking odor, taste, color of the drug, providing physical and chemical protection to drug, Protecting drug from the gastric environment. Tablet coating is the key step involved in the manufacturing of tablets having controlled release, delayed release profiles.
It comprises a mixture of active substances and excipients, usually in powder form, compressed or compacted into a solid. Tablet coating is a process that can be summarized as the application of an “edible paint” to the surface of a pharmaceutical dosage form. In the past, sugar coating was a common solution for coating tablets , but this process has many disadvantages. Each extra-strength pain relief coated tablet contains 5milligrams of acetaminophen and can be a safe and effective post-surgery pain relief option when used as directed. That works against the objective: main - taining a smooth and even flow of the tablet bed throughout the coating process.
The coating all comes off at about the same time in the body and the entire dose is absorbed.
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.